Vol 9: Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients.Report as inadecuate



 Vol 9: Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients.


Vol 9: Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients. - Download this document for free, or read online. Document in PDF available to download.

Download or read this book online for free in PDF: Vol 9: Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients.
This article is from Radiation Oncology London, England, volume 9.AbstractBackground and aims: Stereotactic body radiotherapy SBRT is a relatively new treatment for liver tumor. The outcomes of SBRT for liver tumor unfit for ablation and surgical resection were evaluated. Methods: Liver tumor patients treated with SBRT in seven Japanese institutions were studied retrospectively. Patients given SBRT for liver tumor between 2004 and 2012 were collected. Patients treated with SBRT preceded by trans-arterial chemoembolization TACE were eligible. Seventy-nine patients with hepatocellular carcinoma HCC and 51 patients with metastatic liver tumor were collected. The median biologically effective dose BED α-β = 10 Gy was 96.3 Gy for patients with HCC and 105.6 Gy with metastatic liver tumor. Results: The median follow-up time was 475.5 days in patients with HCC and 212.5 days with metastatic liver tumor. The 2-year local control rate LCR for HCC and metastatic liver tumor was 74.8% ± 6.3% and 64.2 ± 9.5% p = 0.44. The LCR was not different between BED10 ≥ 100 Gy and  30 mm vs. ≤ 30 mm 64% vs. 85%, p = 0.040 in all 130 patients. No grade 3 laboratory toxicities in the acute, sub-acute and chronic phases were observed. Conclusions: There was no difference in local control after SBRT in the range of median BED10 around 100 Gy for between HCC and metastatic liver tumor. SBRT is safe and might be an alternative method to resection and ablation. Summary: There was no difference in local control after SBRT in the range of median BED10 around 100 Gy for between HCC and metastatic liver tumor and SBRT is safe and might be an alternative method to resection and ablation.



Author: Yamashita, Hideomi; Onishi, Hiroshi; Matsumoto, Yasuo; Murakami, Naoya; Matsuo, Yukinori; Nomiya, Takuma; Nakagawa, Keiichi

Source: https://archive.org/



DOWNLOAD PDF




Related documents