Vol 6: Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.Report as inadecuate



 Vol 6: Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.


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This article is from Genome Medicine, volume 6.AbstractThe Killer-cell Immunoglobulin-like Receptor KIR gene complex has considerable biomedical importance. Patterns of polymorphism in the KIR region include variability in the gene content of haplotypes and diverse structural arrangements. Droplet digital PCR ddPCR was used to identify different haplotype motifs and to enumerate KIR copy number variants CNVs. ddPCR detected a variety of KIR haplotype configurations in DNA from well-characterized cell lines. Mendelian segregation of ddPCR-estimated KIR2DL5 CNVs was observed in Gambian families and CNV typing of other KIRs was shown to be accurate when compared to an established quantitative PCR method.



Author: Roberts, Chrissy h; Jiang, Wei; Jayaraman, Jyothi; Trowsdale, John; Holland, Martin J; Traherne, James A

Source: https://archive.org/



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