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 Vol 3: In Vitro High Throughput Screening, What Next Lessons from the Screening for Aurora Kinase Inhibitors.


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This article is from Biology, volume 3.AbstractBased on in vitro assays, we performed a High Throughput Screening HTS to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active molecules. We propose a decision tree that could be adapted to most in vitro HTS.



Author: Hoang, Thi-My-Nhung; Vu, Hong-Lien; Le, Ly-Thuy-Tram; Nguyen, Chi-Hung; Molla, Annie

Source: https://archive.org/



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