Vol 8: In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders.Report as inadecuate



 Vol 8: In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders.


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This article is from Frontiers in Human Neuroscience, volume 8.AbstractPostmortem neuropathology studies report reduced number and size of Purkinje cells PC in a majority of cerebellar specimens from persons diagnosed with autism spectrum disorders ASD. We used diffusion weighted MRI tractography to investigate whether structural changes associated with reduced number and size of PC, could be detected in vivo by measuring streamlines connecting the posterior-lateral region of the cerebellar cortex to the dentate nucleus using an independent component analysis with a ball and stick model. Seed regions were identified in the cerebellar cortex, and streamlines were identified to two sorting regions, the dorsal dentate nucleus DDN and the ventral dentate nucleus VDN, and probability of connection and measures of directional coherence for these streamlines were calculated. Tractography was performed in 14 typically developing children TD and 15 children with diagnoses of ASD. Decreased numbers of streamlines were found in the children with ASD in the pathway connecting cerebellar cortex to the right VDN p-value = 0.015. Reduced fractional anisotropy FA values were observed in pathways connecting the cerebellar cortex to the right DDN p-value = 0.008, the right VDN p-value = 0.010 and left VDN p-value = 0.020 in children with ASD compared to the TD group. In an analysis of single subjects, reduced FA in the pathway connecting cerebellar cortex to the right VDN was found in 73% of the children in the ASD group using a threshold of 3 standard errors of the TD group. The detection of diffusion changes in cerebellum may provide an in vivo biomarker of Purkinje cell pathology in children with ASD.



Author: Jeong, Jeong-Won; Tiwari, Vijay N.; Behen, Michael E.; Chugani, Harry T.; Chugani, Diane C.

Source: https://archive.org/







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