Vol 14: Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer.Report as inadecuate



 Vol 14: Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer.


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This article is from Cancer Cell International, volume 14.AbstractBackground: ORAI1 channels play an important role for breast cancer progression and metastasis. Previous studies indicated the strong correlation between breast cancer and individual single nucleotide polymorphisms SNPs of ORAI1 gene. However, the possible SNP-SNP interaction of ORAI1 gene was not investigated. Results: To develop the complex analyses of SNP-SNP interaction, we propose a genetic algorithm GA to detect the model of breast cancer association between five SNPs rs12320939, rs12313273, rs7135617, rs6486795 and rs712853 of ORAI1 gene. For individual SNPs, the differences between case and control groups in five SNPs of ORAI1 gene were not significant. In contrast, GA-generated SNP models show that 2-SNP rs12320939-GT-rs6486795-CT, 3-SNP rs12320939-GT-rs12313273-TT-rs6486795-TC, 5-SNP rs12320939-GG-rs12313273-TC-rs7135617-TT-rs6486795-TT-rs712853-TT have higher risks for breast cancer in terms of odds ratio analysis 1.357, 1.689, and 13.148, respectively. Conclusion: Taken together, the cumulative effects of SNPs of ORAI1 gene in breast cancer association study were well demonstrated in terms of GA-generated SNP models.



Author: Chang, Wei-Chiao; Fang, Yong-Yuan; Chang, Hsueh-Wei; Chuang, Li-Yeh; Lin, Yu-Da; Hou, Ming-Feng; Yang, Cheng-Hong

Source: https://archive.org/



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