Multiphysics and multiscale modelling, data-model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanicsReport as inadecuate




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1 M3DISIM - Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine LMS - Laboratoire de mécanique des solides, Inria Saclay - Ile de France 2 Imaging Sciences and Biomedical Engineering Division London 3 Université Paris-Saclay 4 Auckland Bioengineering Institute 5 ASCLEPIOS - Analysis and Simulation of Biomedical Images CRISAM - Inria Sophia Antipolis - Méditerranée 6 Departments of Mechanical Engineering, Bioengineering, and Cardiothoracic Surgery, Stanford University, Stanford, CA, 94305-4040, USA 7 Department of Engineering Science, University of Auckland

Abstract : With heart and cardiovascular diseases continually challenging healthcare systems worldwide, translating basic research on cardiac pathophysiology into clinical care is essential. Exacerbating this already extensive challenge is the complexity of the heart, relying on its hierarchical structure and function to maintain cardiovascular flow. Computational modelling has been proposed and actively pursued as a tool for accelerating research and translation. Allowing exploration of the relationships between physics, multiscale mechanisms and function, computational modelling provides a platform for improving our understanding of the heart. Further integration of experimental and clinical data through data assimilation and parameter estimation techniques is bringing computational models closer to use in routine clinical practice. This article reviews developments in computational cardiac modelling and how their integration with medical imaging data is providing new pathways for translational cardiac modelling.

Keywords : heart mechanics cardiac mechanics data-model fusion translational cardiac modelling patient-specific modelling





Author: Radomir Chabiniok - Vicky Wang - Myrianthi Hadjicharalambous - Liya Asner - Jack Lee - Maxime Sermesant - Ellen Kuhl - Alistair Y

Source: https://hal.archives-ouvertes.fr/



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