Immunohistochemical analysis of undifferentiated and poorly-differentiated head and neck malignancies at a tertiary hospital in NigeriaReport as inadecuate




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Head and Neck Oncology

, 2:33

First Online: 03 November 2010Received: 09 September 2010Accepted: 03 November 2010 Absract

This is a retrospective analysis of poorly-differentiated head and neck malignancies at University College Hospital, Ibadan.

Eighty-six poorly-differentiated neoplasms were categorized as carcinomas, sarcomas, lymphomas or neuroendocrine cancers with a panel of 7 antibodies cytokeratin AE1-AE3, vimentin, desmin, myogenin, leukocyte common antigen and neuron-specific enolase. Immunohistochemical and original hematoxylin-eosin diagnoses were contrasted.

The male: female ratio was 2.5:1, with mean age of 38.9 years. Nasopharynx, nose and maxillofacial bones were the most common locations. Immunohistochemistry confirmed 54.8% of carcinomas, 70.6% of sarcomas and 80% of lymphomas.

Hematoxylin-eosin was able to distinguish between sarcoma and lymphoma but differentiation between a carcinoma and neuroendocrine lesion was poor. Further studies are required to maximize the role of immunohistochemistry as an ancillary diagnostic tool in the West African sub-region.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-3284-2-33 contains supplementary material, which is available to authorized users.

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Author: Akinyele O Adisa - Abideen O Oluwasola - Bukola F Adeyemi - Bamidele Kolude - Effiong EU Akang - Jonathan O Lawoyin

Source: https://link.springer.com/



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