3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinomaReport as inadecuate

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Radiation Oncology

, 5:113

First Online: 23 November 2010Received: 29 August 2010Accepted: 23 November 2010


BackgroundTo compare the results of external beam radiotherapy in combination with 3D- computed tomography CT-implanted interstitial high dose rate brachytherapy ERT-3D-HDR-BT versus conventional external beam radiotherapy ERT for the treatment of stage T2b nasopharyngeal carcinoma NPC.

MethodsForty NPC patients diagnosed with stage T2b NPC were treated with ERT-3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy, followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period.

ResultsPatients treated with ERT-3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate 97.5% vs. 80.2%, P = 0.012 and disease-free survival rate 92.5% vs. 73.3%, P = 0.014. Using multivariate analysis, administration of 3D-HDR-BT was found to be favorable for local control P = 0.046 and was statistically significant for disease-free survival P = 0.021. The incidence rate of acute and chronic complications between the two groups was also compared.

ConclusionsIt is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied.

Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-5-113 contains supplementary material, which is available to authorized users.

Yu-Feng Ren, Yuan-Hong Gao contributed equally to this work.

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Author: Yu-Feng Ren - Yuan-Hong Gao - Xin-Ping Cao - Wei-Jun Ye - Bin S Teh

Source: https://link.springer.com/


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