Evaluation of adverse effects in tamoxifen exposed healthy female dogsReport as inadecuate




Evaluation of adverse effects in tamoxifen exposed healthy female dogs - Download this document for free, or read online. Document in PDF available to download.

Acta Veterinaria Scandinavica

, 52:67

First Online: 22 December 2010Received: 06 April 2010Accepted: 22 December 2010

Abstract

BackgroundMammary tumors are among the most frequent neoplasms in female dogs, but the strategies employed in animal treatment are limited. In human medicine, hormone manipulation is used in cancer therapy. Tamoxifen citrate is a selective inhibitor of oestrogen receptors and exerts a potent anti-oestrogen effect on the mammary gland. The aim of this study was to evaluate the adverse effects when exposing healthy female dogs to tamoxifen.

MethodsTamoxifen was administered for 120 days at a dose of 0.5 or 0.8 mg-kg-day to either intact or spayed female dogs. The effects were assessed through clinical examination, haematology, serum biochemistry, ophthalmology and bone marrow aspirate examination. Ovariohysterectomy was performed and the uterus examined by histopathology.

ResultsVulva oedema and purulent vaginal discharge developed with 10 days of tamoxifen exposure in all groups. Pyometra was diagnosed after around 90 days of exposure in intact females with frequencies increasing during the following 30 days of exposure. Up to 50% of dogs within the groups developed retinitis but none of the dogs had signs of reduced visual acuity. The prevalence of retinitis in each group was similar after 120 days of exposure. Haematological, biochemical and bone marrow changes were not observed. Due to the high risk of developing pyometra after prolonged exposure to tamoxifen, only spayed animals should be given this medication.

ConclusionsA dose of 0.8 mg tamoxifen-kg body weight-day is recommended when treating tamoxifen-responsive canine mammary tumors. Due to the high risk of developing pyometra, ovariohysterectomy is recommended.

Electronic supplementary materialThe online version of this article doi:10.1186-1751-0147-52-67 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Wanessa LF Tavares - Gleidice E Lavalle - Mariana S Figueiredo - Aline G Souza - Angelica C Bertagnolli - Fernando AB 

Source: https://link.springer.com/







Related documents