Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetesReport as inadecuate




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Diabetologia

, Volume 52, Issue 7, pp 1426–1433

First Online: 12 May 2009Received: 30 October 2008Accepted: 01 April 2009

Abstract

Aims-hypothesisOxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes.

MethodsWe studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde MDA-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score.

ResultsPatients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease.

Conclusions-interpretationOur observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes.

KeywordsAntibodies Low-density lipoprotein Oxidation Peripheral neuropathy Retinopathy AbbreviationsApoApolipoprotein

CACCoronary artery calcium

CRPC-reactive protein

MDAMalondialdehyde

MPSMyocardial perfusion scintigraphy

IMTIntima–media thickness

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Author: G. N. Fredrikson - D. V. Anand - D. Hopkins - R. Corder - R. Alm - E. Bengtsson - P. K. Shah - A. Lahiri - J. Nilsson

Source: https://link.springer.com/



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