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Abstract: Covariance matrices of amino acid displacements, commonly used tocharacterize the large-scale movements of proteins, are investigated throughthe prism of Random Matrix Theory. Bulk universality is detected in the localspacing statistics of noise-dressed eigenmodes, which is well described by aBrody distribution with parameter $\beta\simeq 0.8$. This finding, supported byother consistent indicators, implies a novel quantitative criterion to singleout the collective degrees of freedom of the protein from the majority ofhigh-energy, localized vibrations.



Author: Raffaello Potestio, Fabio Caccioli, Pierpaolo Vivo

Source: https://arxiv.org/







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