Covariate balance in a Bayesian propensity score analysis of beta blocker therapy in heart failure patientsReport as inadecuate




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Epidemiologic Perspectives and Innovations

, 6:5

First Online: 10 September 2009Received: 11 December 2008Accepted: 10 September 2009

Abstract

Regression adjustment for the propensity score is a statistical method that reduces confounding from measured variables in observational data. A Bayesian propensity score analysis extends this idea by using simultaneous estimation of the propensity scores and the treatment effect. In this article, we conduct an empirical investigation of the performance of Bayesian propensity scores in the context of an observational study of the effectiveness of beta-blocker therapy in heart failure patients. We study the balancing properties of the estimated propensity scores. Traditional Frequentist propensity scores focus attention on balancing covariates that are strongly associated with treatment. In contrast, we demonstrate that Bayesian propensity scores can be used to balance the association between covariates and the outcome. This balancing property has the effect of reducing confounding bias because it reduces the degree to which covariates are outcome risk factors.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-5573-6-5 contains supplementary material, which is available to authorized users.

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Author: Lawrence C McCandless - Paul Gustafson - Peter C Austin - Adrian R Levy

Source: https://link.springer.com/







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