Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved BiocompatibilityReport as inadecuate




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Nanoscale Research Letters

, 5:195

First Online: 25 October 2009Received: 07 September 2009Accepted: 05 October 2009

Abstract

Biocompatible magnetic nanoparticles hold great therapeutic potential, but conventional particles can be toxic. Here, we report the synthesis and alternating magnetic field dependent actuation of a remotely controllable, multifunctional nano-scale system and its marked biocompatibility with mammalian cells. Monodisperse, magnetic nanospheres based on thermo-sensitive polymer network polyethylene glycol ethyl ether methacrylate-co-polyethylene glycol methyl ether methacrylate were synthesized using free radical polymerization. Synthesized nanospheres have oscillating magnetic field induced thermo-reversible behavior; exhibiting desirable characteristics comparable to the widely used poly-N-isopropylacrylamide-based systems in shrinkage plus a broader volumetric transition range. Remote heating and model drug release were characterized for different field strengths. Nanospheres containing nanoparticles up to an iron concentration of 6 mM were readily taken up by neuron-like PC12 pheochromocytoma cells and had reduced toxicity compared to other surface modified magnetic nanocarriers. Furthermore, nanosphere exposure did not inhibit the extension of cellular processes neurite outgrowth even at high iron concentrations 6 mM, indicating minimal negative effects in cellular systems. Excellent intracellular uptake and enhanced biocompatibility coupled with the lack of deleterious effects on neurite outgrowth and prior Food and Drug Administration FDA approval of PEG-based carriers suggest increased therapeutic potential of this system for manipulating axon regeneration following nervous system injury.

KeywordsMagnetic actuation Biomaterials Thermo-sensitive polymers Nano-biotechnology Biocompatibility Neuron  Download fulltext PDF



Author: Santaneel Ghosh - Somesree GhoshMitra - Tong Cai - David R Diercks - Nathaniel C Mills - DiAnna L Hynds

Source: https://link.springer.com/







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