Functional recovery after implantation of artificial nerve grafts in the rat- a systematic reviewReport as inadecuate




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Journal of Brachial Plexus and Peripheral Nerve Injury

, 4:19

First Online: 25 October 2009Received: 25 April 2009Accepted: 25 October 2009

Abstract

PurposeThe aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review.

Materials and methodsA systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model.

ResultsThere was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome.

ConclusionSchwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.

AbbreviationsSFIsciatic functional index

PLLApolyl-lactic acid

PLGApolylactide-coglycolide

TMC-CLtrimethylenecarbonate-co-epsilon-caprolactone

PDLLApolyD, L-lactide

CMAPcompound motor action potential.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-7221-4-19 contains supplementary material, which is available to authorized users.

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Author: Nektarios Sinis - Armin Kraus - Nikolaos Tselis - Max Haerle - Frank Werdin - Hans-Eberhard Schaller

Source: https://link.springer.com/



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