The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancerReport as inadecuate




The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer - Download this document for free, or read online. Document in PDF available to download.

Journal of Experimental and Clinical Cancer Research

, 28:144

First Online: 24 November 2009Received: 03 September 2009Accepted: 24 November 2009

Abstract

BackgroundTo detect the expression of multidrug resistance molecules P-glycoprotein P-gp, Lung resistnce protein LRP and Multidrug resistance-associated protein MRP and analyze the relationship between them and the clinico-pathological features.

MethodsThe expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase SP immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data. None of these patients received chemotherapy prior to surgery.

ResultsThe positive rates of P-gp, LRP, MRP were 86.4%, 84.7% and 27.1%, respectively. The difference between the positive rate of P-gp and MRP was significant statistically, as well as the difference between the expression of MRP and LRP. No significant difference was observed between P-gp and LRP, but the positively correlation between the expression of P-gp and LRP had been found. No significant correlation between the expression of P-gp, LRP, MRP and the grade of differentiation were observed. The expression of P-gp was correlated with clinical stages positively r = 0.742, but the difference with the expression of P-gp in different stages was not significant.

ConclusionThe expressions of P-gp, LRP and MRP in patients with gastric cancer without prior chemotherapy are high, indicating that innate drug resistance may exist in gastric cancer.

List of abbreviationsGCgastric cancer

MDRmultidrug resistance

P-gpP-glycoprotein

MRPMultidrug resistance-associated protein

LRPLung resistance protein.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-28-144 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Wen-Qing Hu - Chun-Wei Peng - Yan Li

Source: https://link.springer.com/







Related documents