Undertreatment of osteoporosis in the oldest old A nationwide study of over 700,000 older peopleReport as inadecuate




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Archives of Osteoporosis

, Volume 4, Issue 1–2, pp 17–23

First Online: 19 March 2009Received: 02 December 2008Accepted: 11 February 2009

Abstract

SummaryWe analysed data from elderly people registered in the Swedish Prescribed Drug Register to investigate whether age is associated with use of osteoporosis drugs in a nationwide population. Our results indicate an undertreatment of osteoporosis, particularly with bisphosphonates, in the oldest old in Sweden.

IntroductionThe aim of this study was to investigate whether age is associated with use of osteoporosis drugs in a large population of older people.

MethodsWe analysed data on age, sex, type of residential area urban-rural and dispensed drugs for people aged ≥75 years registered in the Swedish Prescribed Drug Register from October to December 2005 n = 731,105. Multivariate logistic regression was used to analyse whether age was associated with use of osteoporosis drugs, after adjustment for type of residential area and number of other drugs a proxy for comorbidity.

ResultsOsteoporosis drugs were used by 16.1% of the women and 3.4% of the men. The probability of use of bisphosphonates declined with increasing age ORwomen = 0.36 95% CI 0.34–0.38 and ORmen = 0.46 95% CI 0.37–0.56 for age ≥90 years vs. 75–79 years. Raloxifene was also negatively associated with age. Calcium + vitamin D supplements, however, showed a divergent pattern regarding age. In women, the lowest likelihood of use of calcium + vitamin D supplements occurred in the oldest old ≥90 years.

ConclusionsOur results indicate an undertreatment of osteoporosis, particularly with bisphosphonates, in the oldest old in Sweden. Future research is needed for understanding the mechanisms behind this age effect.

KeywordsBisphosphonates Calcium + vitamin D supplements Drug register Elderly Raloxifene Register-based research  Download fulltext PDF



Author: Kristina Johnell - Johan Fastbom

Source: https://link.springer.com/



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