Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegalyReport as inadecuate




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Pituitary

, Volume 12, Issue 4, pp 339–346

First Online: 12 June 2009Received: 01 May 2009Accepted: 03 May 2009

Abstract

The aim of this study was to assess the effects of replacement with recombinant human growth hormone rhGH in patients with GH deficiency GHD after treatment of acromegaly. Intervention study. Sixteen patients 8 men, age 56 years, treated for acromegaly by surgery and radiotherapy, with an insufficient GH response to insulin-induced hypoglycaemia, were treated with 1 year of rhGH replacement. Study parameters were assessed at baseline and after 1 year of rhGH replacement. Study parameters were cardiac function, body composition, bone mineral density BMD, fasting lipids, glucose, bone turnover markers, and Quality of Life QoL. During rhGH replacement IGF-I concentrations increased from −0.4 ± 0.7 to 1.0 ± 1.5 SD P = 0.001, with a mean daily dose of 0.2 ± 0.1 mg in men and 0.3 ± 0.2 mg in women. Nonetheless, rhGH replacement did not alter cardiac function, lipid and glucose concentrations, body composition or QoL. Bone turnover markers PINP and β crosslaps levels increased P = 0.005 and P = 0.021, respectively, paralleled by a small, but significant decrease in BMD of the hip. The beneficial effects of rhGH replacement in patients with GHD during cure from acromegaly are limited in this study.

KeywordsGrowth hormone deficiency Growth hormone replacement Acromegaly  Download fulltext PDF



Author: Agatha A. van der Klaauw - Jeroen J. Bax - Ferdinand Roelfsema - Marcel P. M. Stokkel - Gabe B. Bleeker - Nienke R. B

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