Clinical Efficacy and Safety of a Combined Loratadine-Betamethasone Oral Solution in the Treatment of Severe Pediatric Perennial Allergic RhinitisReport as inadecuate




Clinical Efficacy and Safety of a Combined Loratadine-Betamethasone Oral Solution in the Treatment of Severe Pediatric Perennial Allergic Rhinitis - Download this document for free, or read online. Document in PDF available to download.

World Allergy Organization Journal

, Volume 2, Issue 4, pp 49–53

First Online: 15 April 2009

Abstract

BackgroundAllergic rhinitis is a highly prevalent condition, particularly among children, whose schoolwork and quality of life may be impaired by its symptoms.

MethodsIn this prospective, multicenter study, children between 6 and 12 years old with a diagnosis of severe perennial allergic rhinitis received a combination of the nonsedating antihistamine loratadine and the corticosteroid betamethasone in an oral solution for 5 days.

ResultsThe total nasal and ocular symptom score was significantly reduced from 11.4 ± 2.1 before treatment to 2.9 ± 2.4 after treatment P < 0.01. Significant reductions P < 0.01 were also observed for sneezing, nasal pruritus, nasal congestion, rhinorrhea, postnasal drip, and ocular erythema and pruritus. No adverse events were reported, and no subject discontinued treatment.

ConclusionsThe combination of loratadine and betamethasone in an oral solution was safe and effective as initial short-term treatment for symptoms of severe perennial allergic rhinitis in school-aged children.

Keywordsetamethasone loratadine pediatric perennial allergic rhinitis quality of life  Download fulltext PDF



Author: Teolinda Mendoza de Morales - Francis Sánchez

Source: https://link.springer.com/



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