Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection courseReport as inadecuate




Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course - Download this document for free, or read online. Document in PDF available to download.

Retrovirology

, 5:33

First Online: 17 April 2008Received: 29 February 2008Accepted: 17 April 2008

Abstract

Immunotherapy of feline immunodeficiency virus FIV-infected cats with monocyte-derived dendritic cells MDCs loaded with aldrithiol-2 AT2-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4 T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-5-33 contains supplementary material, which is available to authorized users.

Giulia Freer, Donatella Matteucci contributed equally to this work.

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Author: Giulia Freer - Donatella Matteucci - Paola Mazzetti - Francesca Tarabella - Enrica Ricci - Leonia Bozzacco - Antonio Merico

Source: https://link.springer.com/







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