Risk assessment does not explain high prevalence of gestational diabetes mellitus in a large group of Sardinian womenReport as inadecuate




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Reproductive Biology and Endocrinology

, 6:26

First Online: 02 July 2008Received: 16 January 2008Accepted: 02 July 2008

Abstract

BackgroundA very high prevalence 22.3% of gestational diabetes mellitus GDM was recently reported following our study on a large group of Sardinian women. In order to explain such a high prevalence we sought to characterise our obstetric population through the analysis of risk factors and their association with the development of GDM.

MethodsThe prevalence of risk factors and their association with the development of GDM were evaluated in 1103 pregnancies 247 GDM and 856 control women. The association of risk factors with GDM was calculated according to logistic regression. Sensitivity and specificity of risk assessment strategy were also calculated.

ResultsNone of the risk factors evaluated showed an elevated frequency in our population. The high risk patients were 231 20.9%. Factors with a stronger association with GDM development were obesity OR 3.7, 95% CI 2.08–6.8, prior GDM OR 3.1, 95% CI 1.69–5.69, and family history of Type 2 diabetes OR 2.6, 95% CI 1.81–3.86. Only patients over 35 years of age were more represented in the GDM group 38.2% vs 22.6% in the non-GDM cases, P < 0.001. Type 2 diabetes in second-degree relatives was equally represented in GDM and non-GDM subjects, while prior poor obstetrical outcomes mostly characterized non-GDM women 17.5% vs 10.6%, P < 0.001. The -average risk- assessment better characterized non-GDM patients 76.8% vs 57.8%, P < 0.001. The logistic regression analysis confirmed that Type 2 diabetes in second-degree relatives, prior poor obstetrical outcomes and the -average risk- definition did not predict the development of GDM.

ConclusionSuch a high prevalence of GDM in our population does not seem to be related to the abnormal presence of some known risk factors, and appears in contrast with the prevalence of Type 2 diabetes in Sardinia. Further studies are needed to explain the cause such a high prevalence of GDM in Sardinia. The -average risk- definition is not adequate to predict GDM in our population.

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Author: Cinzia Murgia - Rachele Berria - Luigi Minerba - Simonetta Sulis - Michela Murenu - Elaine Portoghese - Nicoletta Garau - P

Source: https://link.springer.com/







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