The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sampleReport as inadecuate




The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sample - Download this document for free, or read online. Document in PDF available to download.

BMC Geriatrics

, 8:14

First Online: 14 July 2008Received: 02 March 2008Accepted: 14 July 2008

Abstract

BackgroundWhile the evidence of an association between the apolipoprotein E APOE *E4 allele and Alzheimer-s disease is very strong, the effect of the *E4 allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20–24, 40–44 or 60–64 years.

MethodsIn this four year follow-up study, we reexamine the effect of *E4 in the sample of 2,021 individuals, now aged 65–69 years.

ResultsPerformance on the Mini-Mental State Examination MMSE was significantly poorer for *E4 homozygotes than heterozygotes or non-carriers. The effects of the *E4 genotype on cognitive decline over four years were found on the MMSE and Symbol-Digit Modalities test but only when controlling for risk factors such as head injury and education. Analyses were repeated with the exclusion of participants diagnosed with a mild cognitive disorder, with little change.

ConclusionIt is possible that *E4 carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65–69 years of age.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2318-8-14 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Helen Christensen - Philip J Batterham - Andrew J Mackinnon - Anthony F Jorm - Holly A Mack - Karen A Mather - Kaarin 

Source: https://link.springer.com/







Related documents