Threshold for detection of diabetic peripheral sensory neuropathy using a range of research grade monofilaments in persons with Type 2 diabetes mellitusReport as inadecuate




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Journal of Foot and Ankle Research

, 1:9

First Online: 11 September 2008Received: 18 May 2008Accepted: 11 September 2008

Abstract

AimsTo identify the threshold of reduced sensory perception in Type 2 diabetes mellitus Type 2 DM using a range of research grade monofilaments.

MethodsThree groups of participants were recruited into a between subject, cross-sectional study. Group 1NEW, persons with Type 2 DM diagnosed for less than 2 years n = 80; Group 2 EST persons with Type 2 DM diagnosed for more than 2 years n = 91, and Group 3, a Comparison group without Type 2 DM n = 73, resulted in a total study population, n = 244. Research grade monofilaments 2, 4, 6, 8 and 10-gram were employed using standardised protocol, at 6 sites on the plantar aspect of both feet. The demographic and anthropometric measures of gender, age, height, weight, body mass index BMI, blood pressure and duration of Type 2 DM since diagnosis if applicable of the participants were analysed.

ResultsPerception of the research grade monofilaments differed significantly between the 3 groups p < 0.05. The 6-gram monofilament was found to be the threshold of normal perception, based on 90% of the Comparison group perceiving the 6-gram monofilament at all sites in contrast to 64% of NEW and 48% of EST groups.

ConclusionThe 6-gram monofilament was identified as the threshold of normal sensory perception. Inability to perceive the 6-gram monofilament indicates, when using the method described in this study, that diminution of sensory perception is evident. Employing a range of monofilaments, 6, 8 and 10-grams in Type 2 DM foot screening would allow the clinical detection of deteriorating sensory perception and enable implementation of foot protection strategies at an earlier stage than is currently practised.

AbbreviationsANOVAanalysis of variance

DMdiabetes mellitus

DPSNdiabetic peripheral sensory neuropathy

ESTparticipants diagnosed with Type 2 diabetes for more than 2 years

MTPJmetatarso-phalangeal joint

NEWparticipants diagnosed with Type 2 diabetes for less than 2 years.

Electronic supplementary materialThe online version of this article doi:10.1186-1757-1146-1-9 contains supplementary material, which is available to authorized users.

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Author: Mary P Thomson - Julia Potter - Paul M Finch - Richard B Paisey

Source: https://link.springer.com/



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