Peste des Petits Ruminants PPR in Ethiopia: Analysis of a national serological surveyReport as inadecuate




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BMC Veterinary Research

, 4:34

First Online: 12 September 2008Received: 22 April 2008Accepted: 12 September 2008

Abstract

BackgroundPeste des petits ruminants PPR is a contagious viral disease of small ruminants in Africa and Asia. In 1999, probably the largest survey on PPR ever conducted in Africa was initiated in Ethiopia where 13 651 serum samples from 7 out of the 11 regions were collected and analyzed by competitive enzyme-linked immunosorbent assay cELISA. The objective of this paper is to present the results of this survey and discuss their practical implications for PPR-endemic regions.

MethodsWe explored the spatial distribution of PPR in Ethiopia and we investigated risk factors for positive serological status. Intracluster correlation coefficients ρ, were calculated for 43 wereda administrative units.

ResultsSeroprevalence was very heterogeneous across regions and even more across wereda, with prevalence estimates ranging from 0% to 52.5%. Two groups of weredas could be distinguished on the basis of the estimated ρ: a group with very low ρ ρ < 0.12 and a group with very high ρ ρ > 0.37.

ConclusionThe results indicate that PPRV circulation has been very heterogeneous, the values for the ρ may reflect the endemic or epidemic presence of the virus or the various degrees of mixing of animals in the different areas and production systems. Age appears as a risk factor for seropositive status, the linear effect seeming to confirm in the field that PPRV is highly immunogenic. Our estimates of intracluster correlation may prove useful in the design of serosurveys in other countries where PPR is of importance.

AbbreviationsADBAfrican Development Bank

cDNAcomplementary DeoxyriboNucleic Acid

cELISAcompetitive Enzyme-Linked Immunosorbent Assay

EDIELISA Data Information

FAOFood and Agriculture Organization

GDPGross Domestic Product

IAEAInternational Atomic Energy Agency

IBRInfectious Bovine Rhinotracheitis

NAHRCNational Animal Health Research Center

NLDPNational Livestock Development Project

ODOptical Density

PIPercentage Inhibition

PPRPeste des Petits Ruminants

PPRVPeste des Petits Ruminants virus

ρintracluster correlation coefficient.

Electronic supplementary materialThe online version of this article doi:10.1186-1746-6148-4-34 contains supplementary material, which is available to authorized users.

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Author: Agnès Waret-Szkuta - François Roger - David Chavernac - Laikemariam Yigezu - Geneviève Libeau - Dirk U Pfeiffer - Javier

Source: https://link.springer.com/







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