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Lipids in Health and Disease

, 7:34

First Online: 30 September 2008Received: 16 July 2008Accepted: 30 September 2008


Conjugated linoleic acid CLA, a naturally occurring anticarcinogen found in dairy products, is an intermediary product of ruminal biohydrogenation of polyunsaturated fatty acids. Few data exist on the CLA content of the human blood plasma. The determination of a -normal- content could help in estimating if a person consumes satisfactory amounts of CLA with the diet and thus takes advantage of its potential beneficial effects on health. The purpose of this study was to compare the plasma CLA content of individuals not consuming dairy products group 1, n = 12, individuals consuming normal amounts of dairy products group 2, n = 77 and individuals consuming CLA supplement group 3, n = 12. The only CLA isomer that presented higher percentage than the detection limit 0.03% of total fatty acids was rumenic acid cis9, trans11-octadecadienoic acid. An interesting finding is that compared to the other two groups, group 3 members show the highest average plasma content in rumenic acid, i.e. 0.20% of total fatty acids. The present study could be characterized as the first step in the direction of establishing a normal CLA content of human plasma. Based on these results, it could be suggested that the lower limit of the plasma CLA content is approximately 0.1% of total fatty acids.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-7-34 contains supplementary material, which is available to authorized users.

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Author: Spiros N Zlatanos - Kostas Laskaridis - Angelos Sagredos


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