Comparison of glycaemic control in patients with Type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot studyReport as inadecuate




Comparison of glycaemic control in patients with Type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study - Download this document for free, or read online. Document in PDF available to download.

Acta Diabetologica

, 46:67

First Online: 22 November 2008Received: 18 September 2008Accepted: 16 October 2008

Abstract

This randomised, open-label, two-way cross-over study compared the coefficient of variance CV of fasting and postprandial blood glucose FBG and PPBG with insulin glargine glargine versus neutral protamine Hagedorn NPH insulin treatment in patients with Type 2 diabetes T2DM. Patients N = 20 on oral antidiabetic drugs OADs were treated with NPH at bedtime or glargine at dinnertime for 12 weeks of each cross-over treatment period; OADs were continued. The FBG CV was calculated from self-monitored BG values and PPBG using venous blood samples, or continuous glucose monitoring system CGMS. Both insulins provided similar improvements in glycaemic control; however, PPBG was significantly lower after a standard meal test performed at 13:00 h the day after insulin injection with glargine versus NPH p = 0.02. Thirteen versus 15 patients experienced ≥1 episode of hypoglycaemia with glargine versus NPH. The results suggest that glargine plus OADs is more effective in reducing PPBG fluctuations during the day than NPH plus OADs.

KeywordsT2DM Glycaemic control Insulin glargine Neutral protamine Hagedorn Fasting blood glucose Postprandial blood glucose Results from this study have been presented as a poster at the American Diabetes Association annual congress 2007 Diabetes 2007; 56Suppl 1: A148

Abstract 555-P.

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Author: G. De Mattia - O. Laurenti - A. Moretti

Source: https://link.springer.com/







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