Comparative study of patients with chronic hepatitis C virus infection due to genotypes 1 and 3 referred for treatment in southeast BrazilReport as inadecuate




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BMC Infectious Diseases

, 8:164

First Online: 04 December 2008Received: 28 May 2008Accepted: 04 December 2008

Abstract

BackgroundThe progression of liver disease in patients with chronic hepatitis C virus HCV infection is influenced by host and viral factors. Distinct clinical outcomes in patients infected with different HCV genotypes have been described in the literatute. However, the association between specific HCV genotype and clinical outcome remains unclear. We set out to study the natural history of HCV genotype 1 and 3 infections in Campinas, São Paulo state, Brazil, focusing on epidemiological, clinical, biochemical, and histological characteristics.

MethodsPatients with HCV infection referred for treatment between January 2003 and December 2006 were included in this study. We collected epidemiological, clinical, and laboratorial data using standard forms.

ResultsA total of 283 patients were included; genotype 1 was idenfied in 163 57.6% patients, genotype 3 in 112 39.6%, genotype 2 in 7 2.5%, and genotype 4 in 1 0.35%. Patients with genotype 2 and 4 were excluded from analysis. Multivariate analysis showed that intravenous energetic drug, positive cryoglobulin, and cirrhosis were independently and significantly associated with HCV genotype 3 p < 0.05.

ConclusionGenotype 3 currently seems to be associated with intravenous energetic drug, high frequency of cryoglobulinemia, and advanced liver disease in our region. Understanding the distribution of the different HCV genotypes can elucidate transmission of HCV and support optimal prevention strategies.

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Author: Aline G Vigani - Maria H Pavan - Raquel Tozzo - Eduardo SL Gonçales - Adriana Feltrin - Viviane C Fais - Maria SK Laz

Source: https://link.springer.com/



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