MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology ModelsReport as inadecuate




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1 University of Florida Gainesville 2 XPOP - Modélisation en pharmacologie de population Inria Saclay - Ile de France 3 CMAP - Centre de Mathématiques Appliquées - Ecole Polytechnique

Abstract : Quantitative systems pharmacology QSP models are progressively entering the arena of contemporary pharmacology. The efficient implementation and evaluation of complex QSP models necessitates the development of flexible computational tools that are built into QSP mainstream software. To this end, we present MatVPC, a versatile MATLAB-based tool that accommodates QSP models of any complexity level. MatVPC executes Monte Carlo simulations as well as automatic construction of visual predictive checks VPCs and quantified VPCs QVPCs. VPC is a model diagnostic tool that facilitates the evaluation of both the structural and the stochastic part of a model. It is constructed by superimposing the observations over the model simulations while accounting for both the interindivid-ual variability as well as the residual variability. 1 Once underutilized, 2 the VPC now is recognized as one of the most valuable model diagnostics in pharmacological model evaluation. 3–5 Its superiority over comparable diagnostic tools has been established 6 and reflected by the fact that regulatory agencies recommend it as one of the central model diagnostics. 7





Author: Kostas Biliouris - Marc Lavielle - Mirjam Trame -

Source: https://hal.archives-ouvertes.fr/



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