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Behavioral and Brain Functions

, 3:13

First Online: 06 March 2007Received: 02 January 2007Accepted: 06 March 2007

Abstract

BackgroundMuch has been theorized about the emotional properties of the hemispheres. Our review of the dominant hypotheses put forth by Schore, Joseph, Davidson, and Harmon-Jones on hemispheric emotional valences HEV shows that none are supported by robust data. Instead, we propose that individual-s hemispheres are organized to have differing HEVs that can be lateralized in either direction.

MethodsProbe auditory evoked potentials AEP recorded during a neutral and an upsetting memory were used to assess HEV in 28 20 F right-handed subjects who were either victims of childhood maltreatment N = 12 or healthy controls. In a sub-population, we determined HEV by emotional response to lateral visual field stimulation LVFS, in which vision is limited to one, then the other hemifield. We compare a number of morphometric and functional brain measures between individuals who have right-negative versus left-negative HEV.

ResultsUsing AEPs to determine HEV, we found 62% of controls and 67% of maltreated subjects had right negative HEV. There was a strong interaction between HEV-laterality and gender, which together accounted for 60% of individual variability in total grey matter volume GMV. HEV-laterality was associated with differences in hippocampal volume, amygdala-hippocampal ratios, and measures of verbal, visual and global memory. HEV-laterality was associated also with different constellations of symptoms comparing maltreated subjects to controls. Emotional response to LVFS provided a convenient and complementary measure of HEV-laterality that correlated significantly with the HEVs determined by AEPs.

ConclusionOur findings suggest that HEV-laterality, like handedness or gender, is an important individual difference with significant implications for brain and behavioral research, and for guiding lateralized treatments such as rTMS.

Electronic supplementary materialThe online version of this article doi:10.1186-1744-9081-3-13 contains supplementary material, which is available to authorized users.

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Author: Fredric Schiffer - Martin H Teicher - Carl Anderson - Akemi Tomoda - Ann Polcari - Carryl P Navalta - Susan L Andersen

Source: https://link.springer.com/







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