Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective studyReport as inadecuate




Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study - Download this document for free, or read online. Document in PDF available to download.

BMC Infectious Diseases

, 7:63

First Online: 26 June 2007Received: 01 February 2007Accepted: 26 June 2007

Abstract

BackgroundLow vitamin E levels are often found in HIV-1 infection, and studies have suggested that higher levels may decrease the risk of disease progression. However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression.

MethodsVitamin E status was measured in stored samples from the last pre-infection visit for 67 Kenyan women with reliably estimated dates of HIV-1 acquisition. Regression analyses were used to estimate associations between pre-infection vitamin E and plasma viral load, time to CD4 count <200 cells-μL, and mortality.

ResultsAfter controlling for potential confounding factors, each 1 mg-L increase in pre-infection vitamin E was associated with 0.08 log10 copies-mL 95% CI -0.01 to +0.17 higher set point viral load and 1.58-fold higher risk of mortality 95% CI 1.15–2.16. The association between higher pre-infection vitamin E and mortality persisted after adjustment for set point viral load HR 1.55, 95% CI 1.13–2.13.

ConclusionHigher pre-infection vitamin E levels were associated with increased mortality. Further research is needed to elucidate the role vitamin E plays in HIV-1 pathogenesis.

AbbreviationsAIDSAcquired ImmunoDeficiency Syndrome

CCR5Chemokine C-C motif Receptor 5

ELISAEnzyme-Linked ImmunoSorbent Assay

HIVHuman Immunodeficiency Virus

RANTESRegulated on Activation Normal T-Cell Expressed and Secreted

RNARiboNucleic Acid

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Author: Susan M Graham - Jared M Baeten - Barbra A Richardson - Daniel D Bankson - Ludo Lavreys - Jeckoniah O Ndinya-Achola - K

Source: https://link.springer.com/



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