Continuous negative extrathoracic pressure combined with high-frequency oscillation improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in a rabbit model of surfactant depletionReport as inadecuate




Continuous negative extrathoracic pressure combined with high-frequency oscillation improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in a rabbit model of surfactant depletion - Download this document for free, or read online. Document in PDF available to download.

BioMedical Engineering OnLine

, 6:40

First Online: 31 October 2007Received: 10 May 2007Accepted: 31 October 2007

Abstract

BackgroundNegative air pressure ventilation has been used to maintain adequate functional residual capacity in patients with chronic muscular disease and to decrease transpulmonary pressure and improve cardiac output during right heart surgery. High-frequency oscillation HFO exerts beneficial effects on gas exchange in neonates with acute respiratory failure. We examined whether continuous negative extrathoracic pressure CNEP combined with HFO would be effective for treating acute respiratory failure in an animal model.

MethodsThe effects of CNEP combined with HFO on pulmonary gas exchange and circulation were examined in a surfactant-depleted rabbit model. After induction of severe lung injury by repeated saline lung lavage, 18 adult white Japanese rabbits were randomly assigned to 3 groups: Group 1, CNEP extra thoracic negative pressure -10 cmH2O with HFO mean airway pressure MAP, 10 cmH2O; Group 2, HFO MAP, 10 cmH2O; and Group 3, HFO MAP, 15 cmH2O. Physiological and blood gas data were compared among groups using analysis of variance.

ResultsGroup 1 showed significantly higher oxygenation than Group 2, and the same oxygenation with significantly higher mean blood pressure compared to Group 3.

ConclusionAdequate CNEP combined with HFO improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in an animal model of respiratory failure.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-925X-6-40 contains supplementary material, which is available to authorized users.

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Author: Sachie Naito - Takehiko Hiroma - Tomohiko Nakamura

Source: https://link.springer.com/







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