Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone.Report as inadecuate




Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Ostéoporose et Qualité osseuse Site Laennec 2 BIDMC - Orthopedic Biomechanics Laboratory

Abstract : Previous studies have shown that the mechanical properties of trabecular bone are determined by bone volume fraction BV-TV and microarchitecture. The purpose of this study was to explore other possible determinants of the mechanical properties of vertebral trabecular bone, namely collagen cross-link content, microdamage, and mineralization. Trabecular bone cores were collected from human L2 vertebrae n = 49 from recently deceased donors 54-95 years of age 21 men and 27 women. Two trabecular cores were obtained from each vertebra, one for preexisting microdamage and mineralization measurements, and one for BV-TV and quasi-static compression tests. Collagen cross-link content PYD, DPD, and PEN was measured on surrounding trabecular bone. Advancing age was associated with impaired mechanical properties, and with increased microdamage, even after adjustment by BV-TV. BV-TV was the strongest determinant of elastic modulus and ultimate strength r²  = 0.44 and 0.55, respectively. Microdamage, mineralization parameters, and collagen cross-link content were not associated with mechanical properties. These data indicate that the compressive strength of human vertebral trabecular bone is primarily determined by the amount of trabecular bone, and notably unaffected by normal variation in other factors, such as cross-link profile, microdamage and mineralization.

Keywords : bone strength microdamage microarchitecture mineralization collagen cross-links vertebral trabecular bone





Author: Hélène Follet - Stéphanie Viguet-Carrin - Brigitte Burt-Pichat - Baptiste Dépalle - Yohann Bala - Evelyne Gineyts - François

Source: https://hal.archives-ouvertes.fr/



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