The spindle position checkpoint in budding yeast: the motherly care of MENReport as inadecuate




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Cell Division

, 1:2

First Online: 03 April 2006Received: 13 March 2006Accepted: 03 April 2006

Abstract

Mitotic exit and cytokinesis must be tightly coupled to nuclear division both in time and space in order to preserve genome stability and to ensure that daughter cells inherit the right set of chromosomes after cell division. This is achieved in budding yeast through control over a signal transduction cascade, the mitotic exit network MEN, which is required for mitotic CDK inactivation in telophase and for cytokinesis. Current models of MEN activation emphasize on the bud as the place where most control is exerted. This review focuses on recent data that instead point to the mother cell as being the residence of key regulators of late mitotic events.

Electronic supplementary materialThe online version of this article doi:10.1186-1747-1028-1-2 contains supplementary material, which is available to authorized users.

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Author: Simonetta Piatti - Marianna Venturetti - Elena Chiroli - Roberta Fraschini

Source: https://link.springer.com/







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