Role of CD8 cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11Report as inadecuate




Role of CD8 cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11 - Download this document for free, or read online. Document in PDF available to download.

Virology Journal

, 3:22

First Online: 03 April 2006Received: 17 February 2006Accepted: 03 April 2006

Abstract

Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor replication fitness or is mediated by efficient immune-mediated control, 5 macaques were inoculated intravenously with SIVmac1A11. Three animals that were depleted of CD8+ cells at the start of infection had more prolonged viremia with peak virus levels 1 to 2 logs higher than those of 2 animals that received a non-depleting control antibody. Thus, CD8+ cell-mediated immune responses play an important role in controlling SIVmac1A11 replication during acute viremia.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-3-22 contains supplementary material, which is available to authorized users.

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Author: Koen KA Van Rompay - Emily J Blackwood - Gary Landucci - Don Forthal - Marta L Marthas

Source: https://link.springer.com/







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