A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women ISRCTN56071145Report as inadecuate




A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women ISRCTN56071145 - Download this document for free, or read online. Document in PDF available to download.

BMC Pregnancy and Childbirth

, 6:10

First Online: 04 April 2006Received: 17 October 2005Accepted: 04 April 2006

Abstract

BackgroundPrenatal micronutrient combinations with high iron content are associated with high rates of gastrointestinal symptoms. This coupled with nausea and vomiting of pregnancy results in women often discontinuing their multivitamins.

A new prescription supplement PregVit that separates iron from calcium in two tablets – morning and evening, has lower elemental iron content 35 mg, but results in similar extent of iron absorption when compared to another supplement containing 60 mg of elemental iron Materna. The objectives of this study were to compare tolerability and compliance with PregVit vs. a supplement with high iron content Materna, in pregnant women.

MethodsRandomized, crossover open labeled study in 135 pregnant women attending outpatient clinics in Ontario and Quebec.

ResultsUse of PregVit was associated with a 30% reduction in constipation rate as compared to Materna. Both products demonstrated similar compliance rates.

Compliance of Materna was negatively associated with the severity of nausea and vomiting of pregnancy. No such correlation was found for PregVvit.

ConclusionPregVit, a supplement with lower iron content 35 mg, has significantly decreased constipation rates as compared to 60 mg iron- Materna and has similar compliance rates. High iron content in multivitamin supplements is associated with adverse effects in pregnancy.

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Author: Eric Ahn - Nicholas Pairaudeau - Nicholas PairaudeauJr - Yves Cérat - Bernard Couturier - Andre Fortier - Éric Paradis -

Source: https://link.springer.com/



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