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BMC Bioinformatics

, 7:404

First Online: 06 September 2006Received: 19 April 2006Accepted: 06 September 2006

Abstract

BackgroundThe diverse functions of ncRNAs critically depend on their structures. Mutations in ncRNAs disrupting the structures of functional sites are expected to be deleterious. RNA deleterious mutations have attracted wide attentions because some of them in cells result in serious disease, and some others in microbes influence their fitness.

ResultsThe RDMAS web server we describe here is an online tool for evaluating structural deleteriousness of single nucleotide mutation in RNA genes. Several structure comparison methods have been integrated; sub-optimal structures predicted can be optionally involved to mitigate the uncertainty of secondary structure prediction. With a user-friendly interface, the web application is easy to use. Intuitive illustrations are provided along with the original computational results to facilitate quick analysis.

ConclusionRDMAS can be used to explore the structure alterations which cause mutations pathogenic, and to predict deleterious mutations which may help to determine the functionally critical regions. RDMAS is freely accessed via http:-biosrv1.bmi.ac.cn-rdmas.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2105-7-404 contains supplementary material, which is available to authorized users.

Wenjie Shu, Xiaochen Bo, Rujia Liu contributed equally to this work.

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Author: Wenjie Shu - Xiaochen Bo - Rujia Liu - Dongsheng Zhao - Zhiqiang Zheng - Shengqi Wang

Source: https://link.springer.com/







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