First report of an HIV-1 triple recombinant of subtypes B, C and F in Buenos Aires, ArgentinaReport as inadecuate




First report of an HIV-1 triple recombinant of subtypes B, C and F in Buenos Aires, Argentina - Download this document for free, or read online. Document in PDF available to download.

Retrovirology

, 3:59

First Online: 07 September 2006Received: 26 April 2006Accepted: 07 September 2006

Abstract

We describe the genetic diversity of currently transmitted strains of HIV-1 in men who have sex with men MSM in Buenos Aires, Argentina between 2000 and 2004. Nearly full-length sequence analysis of 10 samples showed that 6 were subtype B, 3 were BF recombinant and 1 was a triple recombinant of subtypes B, C and F. The 3 BF recombinants were 3 different unique recombinant forms. Full genome analysis of one strain that was subtype F when sequenced in pol was found to be a triple recombinant. Gag and pol were predominantly subtype F, while gp120 was subtype B; there were regions of subtype C interspersed throughout. The young man infected with this strain reported multiple sexual partners and sero-converted between May and November of 2004. This study reported for the first time the full genome analysis of a triple recombinant between subtypes B, C and F, that combines in one virus the three most common subtypes in South America.

AbbreviationsHIVHuman Immunodeficiency Virus

CRFscirculating recombinant forms

MSMmen who have sex with men

PBMCsperipheral blood mononuclear cells

PCRpolymerase chain reaction

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-3-59 contains supplementary material, which is available to authorized users.

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