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Reproductive Biology and Endocrinology

, 4:S5

First Online: 09 October 2006

Abstract

This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn or blocked and menstrual bleeding ensues. A detailed understanding of these local mechanisms will enhance our knowledge of disturbed endometrial-uterine function – including problems with excessively heavy menstrual bleeding, endometriosis and breakthrough bleeding with progestin only contraception. The development of novel strategies to manage these clinically significant problems depends on such new understanding as does the development of new contraceptives which avoid the endometrial side effect of breakthrough bleeding.

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Author: Hilary OD Critchley - Rodney W Kelly - David T Baird - Robert M Brenner

Source: https://link.springer.com/



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