Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imagingReport as inadecuate




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1 IMIV - Imagerie moléculaire in vivo 2 IMNC - Imagerie et Modélisation en Neurobiologie et Cancérologie

Abstract : The Geant4 Application for Emission Tomography GATE is an advanced open-source software dedicated to Monte-Carlo MC simulations in medical imaging involving photon transportation Positron emission tomography, single photon emission computed tomography, computed tomography and in particle therapy. In this work, we extend the GATE to support simulations of optical imaging, such as bioluminescence or fluo-rescence imaging, and validate it against the MC for multilayered media standard simulation tool for biomedical optics in simple geometries. A full simulation setup for molecular optical imaging bioluminescence and fluo-rescence is implemented in GATE, and images of the light distribution emitted from a phantom demonstrate the relevance of using GATE for optical imaging simulations.

Keywords : Monte-Carlo simulation bioluminescence fluorescence





Author: Vesna Cuplov - Iréne Buvat - Frédéric Pain - Sébastien Jan -

Source: https://hal.archives-ouvertes.fr/



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