Effects of aging and type 2 diabetes on resting and post occlusive hyperemia of the forearm; the impact of rosiglitazoneReport as inadecuate




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BMC Endocrine Disorders

, 5:4

First Online: 24 March 2005Received: 22 October 2004Accepted: 24 March 2005

Abstract

BackgroundBoth Diabetes and ageing are associated with reduced vascular endothelial function. The exact relationship between the 2 and any improvements from the insulin sensitizer rosiglitazone have not been explored.

MethodsThirty controls and sixteen subjects with type 2 diabetes participated in a series of experiments to examine the interrelationships between age, diabetes and endothelial cell function. In subjects with diabetes, the insulin sensitizer rosiglitazone RSG, a drug also known to improve vascular function, was administered for 3 months to see how it altered these relationships. Resting forearm flows RF and blood flows after 4 min of vascular occlusion PF were measured as an index of endothelial cell function.

ResultsRF, measured by venous occlusion plethysmography, was negatively correlated to both age and diabetes. Administration of RSG for 3 months was associated with an increase in the blood flow response to venous occlusion so that it was not significantly different than that of age matched controls. Total PF in control subjects, compared to subjects with diabetes, averaged 56.58 +- 12.57 and 13.6 +- 8.01 cc-100 cc tissue per min respectively, and were significantly different p < 0.01. After 3 months on RSG, differences between PF in the two groups were no longer evident.

ConclusionThese studies suggest a different mechanism causing a reduction in vascular reactivity with aging and diabetes.

AbbreviationsRFResting forearm blood flows

RSGRosiglitazone

PFPost occlusion blood flows

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6823-5-4 contains supplementary material, which is available to authorized users.

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Author: Jerrold Petrofsky - Scott Lee - Maria Cuneo

Source: https://link.springer.com/



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