High Prevalence of Hepatitis B Virus Markers in Romanian Adolescents With Human Immunodeficiency Virus InfectionReport as inadecuate




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Journal of the International AIDS Society

, 7:68

First Online: 25 March 2005

Abstract

BackgroundWe evaluated the frequency of hepatitis coinfection in Romanian adolescents who were diagnosed with human immunodeficiency virus HIV infection prior to 1995.

MethodsOne hundred sixty-one adolescents 13–18 years of age with symptomatic HIV infection, but without signs of hepatic dysfunction, and 356 age-matched, HIV-uninfected controls underwent laboratory testing for markers of parenterally acquired hepatitis virus infection.

ResultsSeventy-eight percent of HIV-infected adolescents had markers of past or present hepatitis B virus HBV infection, as compared with 32% of controls P =.0001. The prevalence of HBV replicative markers was more than 5-fold higher in HIV-infected adolescents as compared with controls: 43.4% vs 7.9% P =.0001, respectively, for hepatitis B surface antigen HBsAg; and 11.2% vs 2.2% P =.0001, respectively, for hepatitis B e antigen HBeAg. The prevalence of HBsAg chronic carriers and the presence of HBV replicative markers was significantly higher in patients with immunologically defined AIDS CD4+ cell counts < 200 cells-mcL: 59.6% vs 34.6% P =.02 for HBsAg and 22.8% vs 5.7%, P =.002 for HBV DNA. After 1 year of follow-up, the proportion of those who cleared the HBeAg was considerably lower in severely immunosuppressed coinfected patients: 4.7% vs 37.1% P =.003. Four additional HIV-infected adolescents became HBsAg-positive over the term of follow-up incidence rate, 24.9-1000 person-years, despite a record of immunization against hepatitis B.

ConclusionA substantial percentage of HIV-infected and HIV-uninfected Romanian adolescents have evidence of past or present HBV infection. In HIV-infected adolescents, the degree of immunosuppression is correlated with persistence of HBV replicative markers, even in the absence of clinical or biochemical signs of liver disease.

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Author: Simona Maria Ruta - Rodica Floarea Matusa - Camelia Sultana - Loredana Manolescu - Claudia A Kozinetz - Mark W Kline - C

Source: https://link.springer.com/



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