Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in Renal Transplant RecipientsReport as inadecuate




Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in Renal Transplant Recipients - Download this document for free, or read online. Document in PDF available to download.

Lipids in Health and Disease

, 4:11

First Online: 19 May 2005Received: 01 March 2005Accepted: 19 May 2005

Abstract

Abstract Hyperlipidemia and increased degree of oxidative stress are among the important risk factors for Atherosclerosis in renal transplant recipients RTR. The Medical treatment of hyperlipidemia in RTR because of drugs side effects has been problematic, therefore alternative methods such as using of Garlic as an effective material in cholesterol lowering and inhibition of LDL Oxidation has been noted. For evaluation of garlic effect on RTR, 50 renal transplant patients with stable renal function were selected and divided into 2 groups. They took one clove of garlic 1 gr by chewing or swallowing for two months, after one month wash-out period, they took garlic by the other route. Results indicated that although lipid profile, BUN, Cr, serum levels of cyclosporine and diastolic blood pressure did not change, Systolic blood pressure decreased from138.2 to 132.8 mmHg p=0.001 and Malondialdehyde MDA decreased from 2.4 to1.7 nmol-ml p=0.009 by swallowing route, Cholesterol decreased from 205.1 to 195.3 mg-dl p=0.03, triglyceride decreased from 195.7 to 174.8 mg-dl p=0.008, MDA decreased from 2.5 to 1.6 nmol-ml p=0.001, systolic blood pressure decreased from 137.5 to 129.8 mmHg p=0.001, diastolic blood pressure decreased from 84.6 to 77.6 mmHg p=0.001 and Cr decreased from 1.51 to 1.44 mg-dl p=0.03 by chewing route too. However HDL, LDL and cyclosporine serum levels had no significant differences by both of swallowing and chewing routes. We conclude that undamaged garlic swallowed had no lowering effect on lipid level of serum. But Crushed garlic chewed reduces cholesterol, triglyceride, MDA and blood pressure. Additionally creatinine reduced without notable decrease in cyclosporine serum levels may be due to cyclosporine nephrotoxicity ameliorating effect of garlic.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-4-11 contains supplementary material, which is available to authorized users.

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Author: Abbas Jabbari - Hassan Argani - Amir Ghorbanihaghjo - Reza Mahdavi

Source: https://link.springer.com/







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