Fatal meningitis in a previously healthy young adult caused by Streptococcus pneumoniaeserotype 38: an emerging serotypeReport as inadecuate




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BMC Infectious Diseases

, 5:38

First Online: 19 May 2005Received: 08 November 2004Accepted: 19 May 2005

Abstract

BackgroundIn December 2001, a fatal case of pneumococcal meningitis in a Marine Corps recruit was identified. As pneumococcal vaccine usage in recruit populations is being considered, an investigation was initiated into the causative serotype.

Case presentationTraditional and molecular methods were utilized to determine the serotype of the infecting pneumococcus. The pneumococcal isolate was identified as serotype 38 PS38, a serotype not covered by current vaccine formulations. The global significance of this serotype was explored in the medical literature, and found to be a rare but recognized cause of carriage and invasive disease.

ConclusionThe potential of PS38 to cause severe disease is documented in this report. Current literature does not support the hypothesis that this serotype is increasing in incidence. However, as we monitor the changing epidemiology of pneumococcal illness in the US in this conjugate era, PS38 might find a more prominent and concerning niche as a replacement serotype.

List of abbreviationsNHRCNaval Health Research Center

CSFcerebrospinal fluid

MLSTmulti-locus sequence typing

PS38pneumococcus serotype 38

ABCActive Bacterial Core Surveillance

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Author: Carolyn I Baker - Christopher P Barrozo - Margaret AK Ryan - Lisa A Pearse - Kevin L Russell

Source: https://link.springer.com/



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