Minimal Important Difference MID of the Dermatology Life Quality Index DLQI: Results from patients with chronic idiopathic urticariaReport as inadecuate




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Health and Quality of Life Outcomes

, 3:36

First Online: 20 May 2005Received: 01 March 2005Accepted: 20 May 2005

Abstract

BackgroundThe Dermatology Quality Life Index DLQI has seen widespread use as a health-related quality of life measure for a variety of dermatological diseases. The purpose of this study was to estimate the minimal important difference MID on the DLQI for patients with chronic idiopathic urticaria CIU.

MethodsData from 2 Phase III clinical trials of patients N = 476 for Study A; N = 468 for Study B with CIU were analyzed separately to estimate the MID for the DLQI for these populations. Both distributional based and anchor based approaches were used for deriving estimates. The anchor based approach relied upon patient self assessments of pruritus severity; the distributional based approaches relied upon estimating the standard error of measurement, as well as one-half the standard deviation of the DLQI from each study.

ResultsThe distributional approaches resulted in estimates of MID ranging from 2.24 to 3.10 for the two studies. The anchor based approach resulted in estimates of 3.21 and 2.97 for the two studies.

ConclusionAn MID for the DLQI in the range of 2.24 to 3.10 is recommended in interpreting results for patients with CIU.

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Author: Richard Shikiar - Gale Harding - Michael Leahy - Richard D Lennox

Source: https://link.springer.com/



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