Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic ratsReport as inadecuate




Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats - Download this document for free, or read online. Document in PDF available to download.

BMC Complementary and Alternative Medicine

, 5:14

First Online: 22 June 2005Received: 10 December 2004Accepted: 22 June 2005

Abstract

BackgroundThis study was undertaken to investigation the effect of Diasulin, a poly herbal drug composed of ethanolic extract of ten medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in alloxan induced diabetes.

MethodsEthanolic extract of Diasulin a, poly herbal drug was administered orally 200 mg-kg body weight for 30 days. The different doses of Diasulin on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides TBARS, and Hydroperoxide and tissue lipids cholesterol, triglyceride, phospholipides and free fatty acids were also estimated in alloxan induced diabetic rats. The effects were compared with glibenclamide.

ResultTreatment with Diasulin and glibenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Diasulin also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Diasulin was comparable with that of glibenclamide.

ConclusionThe decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Diasulin apart from its antidiabetic effect.

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Author: Ramalingam Saravanan - Leelavinothan Pari

Source: https://link.springer.com/







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