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Critical Care

, 9:R601

First Online: 22 September 2005Received: 10 August 2005Accepted: 25 August 2005

Abstract

IntroductionThe introduction of orthogonal polarization spectral OPS imaging in clinical research has elucidated new perspectives on the role of microcirculatory flow abnormalities in the pathogenesis of sepsis. Essential to the process of understanding and reproducing these abnormalities is the method of quantification of flow scores.

MethodsIn a consensus meeting with collaboraters from six research centres in different fields of experience with microcirculatory OPS imaging, premeditated qualifications for a simple, translucent and reproducible way of flow scoring were defined. Consecutively, a single-centre prospective observational validation study was performed in a group of 12 patients with an abdominal sepsis and a new stoma. Flow images of the microcirculation in vascular beds of the sublingual and stoma region were obtained, processed and analysed in a standardised way. We validated intra-observer and inter-observer reproducibility with kappa cross-tables for both types of microvascular beds.

ResultsAgreement and kappa coefficients were >85% and >0.75, respectively, for interrater and intrarater variability in quantification of flow abnormalities during sepsis, in different subsets of microvascular architecture.

ConclusionSemi-quantitative analysis of microcirculatory flow, as described, provides a reproducible and transparent tool in clinical research to monitor and evaluate the microcirculation during sepsis.

AbbreviationsCIconfidence interval

OPSorthogonal polarization imaging.

Electronic supplementary materialThe online version of this article doi:10.1186-cc3809 contains supplementary material, which is available to authorized users.

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Author: E Christiaan Boerma - Keshen R Mathura - Peter HJ van der Voort - Peter E Spronk - Can Ince

Source: https://link.springer.com/







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