Mechanisms of escape phenomenon of spinal cord and brainstem in human rabiesReport as inadecuate




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BMC Infectious Diseases

, 5:104

First Online: 16 November 2005Received: 10 August 2005Accepted: 16 November 2005

Abstract

BackgroundRabies virus preferentially involves brainstem, thalamus and spinal cord in human furious and paralytic rabies beginning in the early stage of illness. Nevertheless, rabies patient remains alert until the pre-terminal phase. Weakness of extremities develops only when furious rabies patient becomes comatose; whereas peripheral nerve dysfunction is responsible for weakness in paralytic rabies.

MethodsEvidence of apoptosis and mitochondrial outer membrane permeabilization in brain and spinal cord of 10 rabies patients was examined and these findings were correlated with the presence of rabies virus antigen.

ResultsAlthough apoptosis was evident in most of the regions, cytochrome c leakage was relatively absent in spinal cord of nearly all patients despite the abundant presence of rabies virus antigen. Such finding was also noted in brainstem of 5 patients.

ConclusionCell death in human rabies may be delayed in spinal cord and the reticular activating system, such as brainstem, thus explaining absence of weakness due to spinal cord dysfunction and preservation of consciousness.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-5-104 contains supplementary material, which is available to authorized users.

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Author: Sasiwimol Juntrakul - Preecha Ruangvejvorachai - Shanop Shuangshoti - Supaporn Wacharapluesadee - Thiravat Hemachudha

Source: https://link.springer.com/







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