Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatisReport as inadecuate




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Genome Biology

, 5:R42

First Online: 18 May 2004Received: 13 February 2004Revised: 26 March 2004Accepted: 01 April 2004

Abstract

By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.

Electronic supplementary materialThe online version of this article doi:10.1186-gb-2004-5-6-r42 contains supplementary material, which is available to authorized users.

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Author: Brian W Brunelle - Tracy L Nicholson - Richard S Stephens

Source: https://link.springer.com/







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