Activity of telithromycin and comparators against bacterial pathogens isolated from 1,336 patients with clinically diagnosed acute sinusitisReport as inadecuate




Activity of telithromycin and comparators against bacterial pathogens isolated from 1,336 patients with clinically diagnosed acute sinusitis - Download this document for free, or read online. Document in PDF available to download.

Annals of Clinical Microbiology and Antimicrobials

, 3:15

First Online: 02 August 2004Received: 15 April 2004Accepted: 02 August 2004

Abstract

BackgroundIncreasing antimicrobial resistance among the key pathogens responsible for community-acquired respiratory tract infections has the potential to limit the effectiveness of antibiotics available to treat these infections. Since there are regional differences in the susceptibility patterns observed and treatment is frequently empirical, the selection of antibiotic therapy may be challenging. PROTEKT, a global, longitudinal multicentre surveillance study, tracks the activity of telithromycin and comparator antibacterial agents against key respiratory tract pathogens.

MethodsIn this analysis, we examine the prevalence of antibacterial resistance in 1,336 bacterial pathogens, isolated from adult and paediatric patients clinically diagnosed with acute bacterial sinusitis ABS.

Results and discussionIn total, 58.0%, 66.1%, and 55.8% of S. pneumoniae isolates were susceptible to penicillin, cefuroxime, and clarithromycin respectively. Combined macrolide resistance and reduced susceptibility to penicillin was present in 200-640 31.3 % of S. pneumoniae isolates 128 isolates were resistant to penicillin MIC >= 2 mg-L, 72 intermediate MIC 0.12–1 mg-L while 99.5% and 95.5% of isolates were susceptible to telithromycin and amoxicillin-clavulanate, respectively. In total, 88.2%, 87.5%, 99.4%, 100%, and 100% of H. influenzae isolates were susceptible to ampicillin, clarithromycin, cefuroxime, telithromycin, and amoxicillin-clavulanate, respectively. In vitro, telithromycin demonstrated the highest activity against M. catarrhalis MIC50 = 0.06 mg-L, MIC90 = 0.12 mg-L.

ConclusionThe high in vitro activity of against pathogens commonly isolated in ABS, together with a once daily dosing regimen and clinical efficacy with 5-day course of therapy, suggest that telithromycin may play a role in the empiric treatment of ABS.

Download fulltext PDF



Author: Joseph Dohar - Rafael Cantón - Robert Cohen - David John Farrell - David Felmingham

Source: https://link.springer.com/







Related documents