Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopiaReport as inadecuate




Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia - Download this document for free, or read online. Document in PDF available to download.

BMC Medical Genetics

, 5:20

First Online: 03 August 2004Received: 15 March 2004Accepted: 03 August 2004

Abstract

BackgroundTo determine whether previously reported loci predisposing to nonsyndromic high myopia show linkage to common myopia in pedigrees from two ethnic groups: Ashkenazi Jewish and Amish. We hypothesized that these high myopia loci might exhibit allelic heterogeneity and be responsible for moderate -mild or common myopia.

MethodsCycloplegic and manifest refraction were performed on 38 Jewish and 40 Amish families. Individuals with at least -1.00 D in each meridian of both eyes were classified as myopic. Genomic DNA was genotyped with 12 markers on chromosomes 12q21-23 and 18p11.3. Parametric and nonparametric linkage analyses were conducted to determine whether susceptibility alleles at these loci are important in families with less severe, clinical forms of myopia.

ResultsThere was no strong evidence of linkage of common myopia to these candidate regions: all two-point and multipoint heterogeneity LOD scores were < 1.0 and non-parametric linkage p-values were > 0.01. However, one Amish family showed slight evidence of linkage LOD>1.0 on 12q; another 3 Amish families each gave LOD >1.0 on 18p; and 3 Jewish families each gave LOD >1.0 on 12q.

ConclusionsSignificant evidence of linkage LOD> 3 of myopia was not found on chromosome 18p or 12q loci in these families. These results suggest that these loci do not play a major role in the causation of common myopia in our families studied.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2350-5-20 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Grace Ibay - Betty Doan - Lauren Reider - Debra Dana - Melissa Schlifka - Heping Hu - Taura Holmes - Jennifer O-Neill - Ro

Source: https://link.springer.com/



DOWNLOAD PDF




Related documents