Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of a prospective trialReport as inadecuate




Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of a prospective trial - Download this document for free, or read online. Document in PDF available to download.

Critical Care

, 8:R437

First Online: 18 October 2004Received: 26 August 2004Accepted: 02 September 2004

Abstract

IntroductionTreating hyperglycaemia in hospitalized patients has proven to be beneficial, particularly in those with obstructive vascular disease. In a cohort of patients undergoing resection for oesophageal carcinoma a group of patients with severe surgical stress but a low prevalence of vascular disease, we investigated whether early postoperative hyperglycaemia is associated with increased incidence of infectious complications and prolonged in-hospital stay.

MethodsPostoperative glucose values up to 48 hours after surgery were retrieved for 151 patients with American Society of Anesthesiologists class I or II who had been previously included in a randomized trial conducted in a tertiary referral hospital. Multivariate regression analysis was used to define the independent contribution of possible risk factors selected by univariate analysis.

ResultsIn univariate regression analysis, postoperative glucose levels were associated with increased length of in-hospital stay P < 0.001 but not with infectious complications P = 0.21. However, postoperative glucose concentration was not found to be an independent risk factor for prolonged in-hospital stay in multivariate analysis P = 0.20.

ConclusionOur data indicate that postoperative hyperglycaemia is more likely to be a risk marker than a risk factor in patients undergoing highly invasive surgery for oesophageal cancer. We hypothesize that patients with a low prevalence of vascular disease may benefit less from intensive insulin therapy.

Keywordshyperglycaemia infection length of stay oesophagectomy risk factor AbbreviationsASAAmerican Society of Anesthesiologists

BMIbody mass index

CIconfidence interval

FEVforced expiratory volume in 1 s

FFAfree fatty acid

ICUintensive care unit

ORodds ratio

SEstandard error.

Electronic supplementary materialThe online version of this article doi:10.1186-cc2970 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Titia M Vriesendorp - JHans DeVries - Jan BF Hulscher - Frits Holleman - Jan J van Lanschot - Joost BL Hoekstra

Source: https://link.springer.com/







Related documents